Promotion chasers Barnsley claimed all three points against the Shrimps at Oakwell on Saturday afternoon.
Three first half goals and two in the second proved the difference between the two sides.
The hosts got off to a perfect start when, on four minutes, a free kick was rocketed on target, Connor Ripley made the initial save, but Devante Cole was on hand to smash home the rebound.
Moments later and the Shrimps looked to respond through Jensen Weir, who was drafted into the XI at late notice, but his strike from the edge of the box sailed over the bar.
Barnsley doubled their advantage just before the midway stage in the first half; A stinging shot from outside the area initially forcing Ripley into a smart save, the resulting cross took a deflection off Dynel Simeu and ended up in the back of the net.
Just after the half-hour mark, Herbie Kane struck from the edge of the box and managed to curl it beyond the reach of Ripley to make it three for the home side.
Half-time: Barnsley 3 Morecambe 0
Eight minutes into the second half and the hosts scored again – Cole found space inside the Shrimps’ box to slot past Ripley, netting his second of the game.
Morecambe looked to pull one back on 67 minutes as Dan Crowley looked to curl one into the bottom corner, but the ball bounced back off the post and Cole Stockton couldn’t find the target with the rebound.
With just over 10 minutes to play, a looping effort from distance courtesy of Papa Souare came close, but it flew just wide of Harry Isted’s right-hand post.
Substitute Josh Austerfield struck from distance after advancing and making good ground, but the consolation proved evasive after the shot was pulled wide.
The Tykes rounded off the scoring with seconds to play in second half added time through Bobby Thomas who met the corner at the back post to head home.
Full-time: Barnsley 5 Morecambe 0
Barnsley: Isted, Williams, Kitching, Andersen, Cadden (Larkeche 71’), Kane (Benson 56’), B Thomas, L Thomas (Phillips, 56’), Cole, Watters (Tedic 66’), Connell (Russell, 56’)
Subs not used: Collins, Norwood.
Goals: Cole (04’, 53’), Simeu OG (21’), Kane (32’), Thomas (90+3’).
Bookings: Kitching.
Red cards: None.
Morecambe: Ripley, Love, Gibson, Rawson (Austerfield, 75’), Crowley (Mayor 75’), Stockton (Hunter 75’), Weir, Bedeau, Niasse, Souare, Simeu.
Subs not used: Smith, Delaney, Watts, Cooney.
Goals: None.
Bookings: None.
Red cards: None.
Attendance: 11,519 (279 away).