The Shrimps were beaten 3-1 by league leaders Plymouth Argyle at the Mazuma Stadium on Good Friday.
Jensen Weir fired the home side in front early on, but second half goals from Danny Mayor, Ben Waine and Jay Matete meant it was the visitors who claimed all three points.
Derek Adams' men made the perfect start after three minutes with counter attack following a Plymouth corner. Dan Crowley sent Weir racing through on goal, his shot beat Argyle goalkeeper Callum Burton and nestled in the back of the net.
Weir had a fantastic opportunity to add to his, and Morecambe's, tally for the afternoon when Liam Gibson fed the ball to him from the left, but the Shrimps' man was unable to get his effort on target from just inside the box.
Plymouth came close to levelling the scoreline just before the break when Mickel Miller crossed from the left to find Joe Edwards, his header was sent wide.
The Reds continued to press for a second and nearly found it when Crowley’s cross from the right flashed across the six-yard box and was cleared away just in time by an Argyle defender.
Half-time: Morecambe 1 Plymouth Argyle 0
The Shrimps began the second half in the ascendancy when Cole Stockton forced a good save out of Burton from inside the Argyle area.
Argyle levelled proceedings just beyond the hour mark when Mayor picked up the ball on the edge of the Morecambe box and curled his effort into the bottom-right corner.
Plymouth almost had a second when Ryan Hardie flicked a header towards goal at the near post, his effort was excellently tipped over the bar by Connor Ripley.
Donald Love wasn’t far away from giving the Shrimps the advantage when he hit one on the half-volley, but the fierce strike flew narrowly wide.
With four minutes of normal time to play, the visitors took the lead when the ball was cut back to Waine from the right, he made no mistake from close range.
The Pilgrims rounded off the scoring when substitutue Matete raced through on goal and beat Ripley with his side footed effort in the third minute of time added on.
Full-time: Morecambe 1 Plymouth Argyle 3
Morecambe: Ripley, Love, Gibson, Rawson, Delaney, Crowley (Watts 71’), Stockton, Weir, Austerfield, Souaré (Mayor, 90’), Simeu (Niasse, 90’).
Subs not used: Smith, Taylor, Gnahoua, Cooney.
Goals: Weir (3’).
Bookings: Rawson, Austerfield.
Red cards: None
Plymouth Argyle: Burton, Houghton (Matete, 83’), Wilson, Scarr, Butcher (Mayor, 57’) , Edwards (Mumba, 75’), Hardie, Miller (Wright, 75’), Cosgrove (Waine, 57’), Galloway, Wright.
Subs not used: Parkes, Lonwijk, Matete.
Goals: Mayor (63’), Waine (87’), Matete (90+3’)
Bookings: Edwards.
Red cards: None.
Attendance: 4,904.