The Shrimps settle for a point at Fratton Park in what was a closely contested Easter Monday fixture.
Despite a number of big chances for either side, the game ended goalless after neither team were able to break the deadlock.
Donald Love produced the first chance of the game for the Shrimps with a fierce, low strike, but the ball was deflected away following a block by a defender.
Moments later and it was Love again causing problems for the hosts, this time he dispossessed a Pompey man before crossing into the path of Cole Stockton, his shot was kept out by Matt Macey down to his left.
Pompey came close to opening the scoring on 14 minutes when a cross was sent to the back post, Colby Bishop was there to meet it, but failed to make any meaningful contact on the ball.
Both sides were creating chances just beyond the midway stage of the first half, with Stockton seeing a powerful effort deflected behind and, moments later, Dane Scarlett managed to break through on goal before rounding Connor Ripley, but his pass back into the mix could only find a red shirt.
Tom Lowery produced two similar chances in four minutes; he picked up the ball to the right of the Morecambe box before sending the shot narrowly wide of the far post.
In what was the final Shrimps' chance before the break, Liam Gibson looked to curl one from 20 yards, but the ball landed comfortably in the arms of Macey.
Half-time: Portsmouth 0 Morecambe 0
The Shrimps looked for a quick start to the second half with Dan Crowley laying the ball through to Stockton who looked to be in on goal, but Macey was off his line quickly to smother the danger.
Four minutes before the hour mark and the Shrimps produced another chance, this time Jensen Weir finding a way through on goal, but his effort was straight at the Pompey goalkeeper.
Substitute Reeco Hackett tested Connor Ripley on 63 minutes after controlling the ball and firing at goal, but the Shrimps’ shot stopper had it covered at his near post.
A huge chance for Pompey saw Dale meet Hackett’s cross, but Stockton was in the right place at the right time to clear the danger off the line.
Hackett again came close with a curling effort from 25 yards out, but the ball sailed over the bar.
Derek Adams' men came agonisingly close to breaking the deadlock four minutes before the 90 after breaking down the right through Weir, his pull back to Jake Taylor saw the substitute send the ball well over the crossbar.
Goalkeeper Ripley was called into action in the final seconds of the game and managed to deny Hackett and point-blank range low down to his left, ensuring the Shrimps left Hampshire with a point in the process.
Full-time: Portsmouth 0 Morecambe 0
Portsmouth: Macey, Rafferty, Raggett, Robertson, Hume, Tunnicliffe (Pigott, 66’), Pack, Lowery, Dale, Bishop, Scarlett (Hackett, 60’).
Subs not used: Oluwayemi, Bernard, Towler, Thompson, Jewitt-White.
Bookings: Dale, Bishop.
Red cards: None.
Morecambe: Ripley, Love, Gibson, Rawson, Delaney, Crowley, Stockton, Weir, Austerfield (Simeu, 87’), Souaré (Cooney, 72’), Mayor (Taylor, 78’).
Subs not used: Smith, Gnahoua, Watts, Niasse.
Bookings: Austerfield, Rawson.
Red cards: None.
Attendance: 17,739 (139).