Morecambe picked up a valuable point with a solid defensive display on their first visit to the new Plough Lane.
With Stephen Robinson back in the dugout after missing the Spurs game with Covid-19, the Shrimps made two changes with Aaron Wildig and Arthur Gnahoua returning to the starting line up as Trevor Carson and Jacob Bedeau made their League debuts for the Club.
In a game of few chances, it was Carson who produced the standout moment with a superb second half save from Ollie Palmer's flick header to secure a clean sheet.
AFC Wimbledon started the game on the front foot with several crosses flashing across the Shrimps' box, but it was the Robinson's men who created the better chances.
Top scorer Cole Stockton was played in on goal, but was denied a shot on target by a superb covering tackle from Ben Heneghan.
The next chance saw former Don Shane McLaughlin find an opening in the box, but his drilled effort could only find the side netting.
Half-time: AFC Wimbledon 0-0 Morecambe
After a sluggish first half, the home side stepped up the pace after the break, but the Shrimps defended superbly.
The hosts' main threat came when striker Palmer got end of a near post cross which Carson flicked over at full stretch.
George Marsh then flashed a shot over from 25 yards before Jack Rudoni curled an effort wide.
Morecambe then produced a late rally with Jonah Ayunga firing well over from the edge of the area as both sides pushed for, but failed to find, a late winner.
Full-time: AFC Wimbledon 0-0 Morecambe
AFC Wimbledon: Tzanev, Alexander, Heneghan, Nightingale, Osew, Marsh, Woodyard, Assal (Kajal 83'), Rudoni (Mebude 83'), McCormick, Palmer (Ablade 88')
Subs not used: Oualah, Lawrence, Chislett, Cosgrave.
Bookings: Marsh 83', Ablade 90+1'
Red Cards: None
Morecambe: Carson, McLaughlin, O'Connor, Bedeau, Leigh, Wildig (Cooney 68'), McLoughlin, Gnahoua (McDonald 75'), Diagouraga, Stockton, Ayunga (McCalmont 90')
Subs not used: Letheren, Jones, Delaney, Gibson.
Bookings: Wildig 58', Leigh 65'